Journal article
RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior
A Kania, A Szlaga, P Sambak, A Gugula, E Blasiak, MV Micioni Di Bonaventura, MA Hossain, C Cifani, G Hess, AL Gundlach, A Blasiak
Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2020
Abstract
Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake in rats through the activation of the relaxin-family peptide-3 receptor (RXFP3). Here we demonstrate that a likely mechanism underlying the orexigenic action of RLN3 is RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecretory cells. Moreover, we reveal that, in male and female rats, this action depends on M-like potassium conductance. Notably, higher intra- and peri-PVN RLN3 fiber densities were observed in females, whic..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by Ministry of Science and Higher Education Poland 0020/DIA/2014/43 to A.K.; National Science Center Poland DEC-2012/05/D/NZ4/02984 to A.B. and UMO-2016/21/B/NZ4/00204 to A.B. and G.H.; Institute of Zoology and Biomedical Research of the Jagiellonian University, Krakow DS/MND/WBiNoZ/IZ/20/2016-K/DSC/003960, DS/MND/WBiNoZ/IZ/16/2017-K/DSC/004650, and DS/MND/WB/IZ/9/2018-K/DSC/005535 to A.K.; National Health and Medical Research Council (Australia) Project Grant 1122170 to M.A.H. and 1067522 to A.L.G.; Sir Edward 'Weary' Dunlop Research Foundation Mental Health Grant to A.L.G.; and Italian Ministry of Education, University and Research PRIN2015KP7T2Y to C.C. A.K. was also supported by the National Science Center PhD Scholarship program ETIUDA V, Poland, UMO-2017/24/T/NZ4/00225. We thank Emanuela Micioni Di Bonaventura (University of Camerino, Italy) for help with the behavioral experiments; and Lukasz Chrobok and Jagoda S. Jeczmien (Jagiellonian University, Krakow, Poland) for help with the neural tract-tracing experiments.